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One approach is to use the intercept term from cross-trait LD score regression [ 40 ]. Thus, the values shown represent the proportional association estimates for each genetic variant on the set of traits. Blane, D. Investigating the various mechanisms or pathways through which BMI could have a causal effect estimate on EDU through trait-enrichment analysis has revealed notable causal effect estimates from two clusters: one with a strongly negative MR estimate, the trait enrichment of which reflects shared mechanisms with socio-economic factors, and another cluster with close to zero causal effect estimate enriched for lean-mass traits.